Purpose To investigate the expression of microRNA-204( miR-204) in fibroblast from ankylosing spondylitis( AS) patients and its effect on bone morphogenetic protein-2( BMP-2) and transforming growth factor-β1( TGF-β1)-induced fibroblast ossification and the potential underlying mechanism. Methods Hip joint capsule tissues were collected from 5 AS patients and 5 non-AS subjects. Primary fibroblast was isolated by primary cell culture method. Cells were divided into four groups: normal group,AS control,AS + m...
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