【摘要】 目的:观察银屑病患者发生勃起功能障碍(ED)的一般情况,研究代谢综合征、抑郁、血浆睾酮水平与银屑病患者发生ED的相关性。方法:用国际勃起功能评分表(IIEF-5)对57例银屑病患者及79例正常男性性功能进行评价,并用抑郁自评量表(CES-D)对参与者抑郁情绪进行评价。同时记录参与者的年龄、身高、体重、血压、血脂、血糖、血清睾酮。结果:IIEF-5评分结果显示57例银屑病患者中30例(52.6%)有ED,79例正常男性中29例(36.7%)有ED。年龄校正的结果显示银屑病组发生ED比例较高,OR值为2.29(95%CI 1.06~4.98)。单因素分析结果显示银屑病患者年龄、代谢综合征、抑郁症是ED发生的危险因素;多因素分析结果显示抑郁症是ED发生的独立危险因素。结论:银屑病患者ED发生率较高,银屑病患者ED的调查可以作为一项临床常规开展项目。更多还原

【Abstract】 Objective: To determine the different prevalence of erectile dysfunction( ED) in psoriasis patients in comparison with a healthy control group,and to explore the association of ED with metabolic syndrome,depressive symptoms and hormonal factors in psoriasis. Methods: Fiftyseven psoriasis patients and 79 control men were interviewed by their doctors and completed a questionnaire containing the five-item version of the International Index of Erectile Function( IIEF-5) and the Center for Epidemiologic Studies Depression Scale( CES-D). The information on age,BMI,blood pressure,serum lipid,blood sugar and serum testosterone level were also collected.Results: Thirty of 57( 52. 6%) patients with psoriasis recorded an IIEF-5 score indicative of ED,compared with 29 of 79( 36. 7%) in control group,reflecting an age-adjusted odds ratio of 2. 29 in favour of the psoriasis group( 95% CI 1. 06-4. 98). A univariate analysis in the psoriasis group indicated that age( per 5 years),metabolic syndrome and depressive symptoms were the risk factors for ED. The multivariate logistic regression model indicated that depressive symptoms was an independent risk factor for ED in psoriasis. Conclusions: The incidence of ED is higher in patients with psoriasis. Screening of ED should become a part of routine care in the management of psoriasis patients.更多还原