【摘要】 目的探讨表皮生长因子受体在宫颈癌中的表达及其临床病理意义。方法选取2009年到2011年经历外科手术的36例宫颈癌患者的组织标本,通过免疫组织化学方法检测其EGFR蛋白的表达,分析EGFR表达水平与宫颈癌患者临床病理特征及2年生存率的相关性。结果宫颈癌组织中EGFR的表达显著强于正常宫颈上皮,但其与宫颈癌患者的年龄、肿瘤的组织学类型、临床分型和有否淋巴结转移均无显著相关性(P>0.05),与宫颈癌患者术后2年生存率显著相关(P<0.05)。预后差的宫颈癌组织中EGFR表达强度显著高于预后较好的宫颈癌组织,差异有统计学意义(P<0.05)。结论 EGFR在宫颈癌组织中的表达上调,可能参与了宫颈癌的发生和发展,并与宫颈癌的不良预后密切相关。更多还原

【Abstract】 Objective To investigate the expression of epidermal growth factor receptor(EGFR) in cervical cancer and its clinicopathological significance. Methods In tumors from 36 patients with stage Ⅰ and Ⅱ cancer of the uterine cervix, the expression of EGFR was studied using immunohistochemistry. Then the correlations of the EGFR expressions were analyzed with the clinicopathologic features and their 2-year survival rates. Results EGFR expression was significantly higher in the cancer tissues than in the normal cervix tissues. The expression levels of EGFR were not correlated with the age of patients, tumor histological types and lymph node metastases, but significantly correlated with the 2-year survival rate after operation. The EGFR expression in cervical cancer tissues with poor prognosis was significantly higher than in those with good prognosis(P<0.05). Conclusion The overexpression of EGFR in cervical cancer tissues may get involved in the development of cervical cancer and closely related with the poor prognosis.更多还原