【摘要】 目的 探讨幽门螺杆菌(Hp)、血管内皮生长因子(VEGF)与肠上皮化生、上皮内瘤变的相互关系,进一步了解Hp根除治疗对肠上皮化生和上皮内瘤变VEGF表达的影响。方法 选取门诊及胃镜室患者根据病理结果 分为肠上皮化生和上皮内瘤变二组,分别测定Hp及VEGF的表达,分析比较Hp及根除治疗对胃黏膜肠上皮化生和上皮内瘤变中VEGF表达的影响。结果 在肠上皮化生、上皮内瘤变中VEGF的表达Hp阳性组均较阴性组升高,差异有统计学意义(P<0.05)。肠上皮化生组根除前后VEGF表达阳性率分别为76.5%(26/34)、66.7%(20/30),在上皮内瘤变组根除前后VEGF表达阳性率分别为80%(36/45)、73.8%(31/42),可见VEGF的表达均较治疗前下降,但差异无统计学意义(P>0.05)。结论 Hp对VEGF表达有上调作用,根除治疗后VEGF表达不能降至正常。更多还原

【Abstract】 Objective To investigate the relationships Helicobacter pylori,VEGF,intestinal metaplasia,and intraepithelial neoplasia,to further understand the mechanisms of H.pylori pathogenic mechanisms in intestinal metaplasia and intraepithelial neoplasia.Methods Patients from outpatient and endoscopy room were divided into intestinal metaplasia and intraepithelial neoplasia groups based on pathological findings.Helicobacter pylori and VEGF expression were measured respectively.and the change was analysised and compared VEGF expression after Hp eradication for gastric intestinal metaplasia and intraepithelial neoplasia.Results The VEGF expression of H.pylori-positive tissues was higher than H.pylori-negative ones in intestinal metaplasia and neoplastic epithelial groups,the difference was statistically significant(P<0.05).The expression of VEGF compared before and after the eradication was 76.5%,66.7%in intestinal metaplasia group and 80%,73.8%.In intraepithelial neopIasia.The VEGF expression decreased after Helicobacter pylori eradication treatment,but the difference was not statistically significant(P>0.05).Conclusion Helicobacter pylori upregulated of VEGF expression,however VEGF expression after eradication therapy is not returned to normal.更多还原