【摘要】 目的 探讨水通道蛋白1（AQP1）和P57^kip2在食管鳞状细胞癌组织中的表达和分布特点,及二者在食管鳞癌表达中的相关性及与肿瘤转移的关系。方法 采用免疫组织化学方法 （SP法）检测75例食管鳞癌患者手术标本癌组织及癌旁组织中AQP1和P57^kip2的表达水平,并与淋巴结转移数进行分析。结果 鳞癌组织中AQP1阳性表达率70.7%（53/75）,明显高于癌旁组织29.3%（22/75）（x²=25.626,P<0.01）;有淋巴结转移的鳞癌组织中AQP1阳性表达率87.5%（28/32）,高于无淋巴结转移58.1%（25/43）,差异有统计学意义（P<0.05）;P57^kip2在鳞癌组织中阳性表达率33.3%（25/75）低于正常组织77.3%（58/75）（P<0.05）,且与食管鳞癌组织淋巴结转移有关（P<0.05）;AQP1和P57^kip2在食管鳞癌中的表达呈负相关（r=-0.849,P<0.01）。结论 AQP1高表达可能与食管癌的发生发展有关;AQP1和P57^kip2联合检测可作为评估食管癌转移与预后的指标。更多还原

【Abstract】 Objective To investigate the expression and distribution of aquaporin-1（AQP1） and P57^kip2 in esophageal squamous cell carcinoma（ESCC）and to explore the correlation between AQP1 and P57^kip2 in ESCC.Methods Immunohistoehemical method（SP method）was used to detect the expression of AQP1 and P57^kip2in 75 cases of ESCC tissue and the normal tissue of the ESCC patients.And node metastasis were statistically comparative analysis.Results The positive rate of AQP1 was 70.7%（53/75）in ESCC,significantly higher than that in the normal tissue of the ESCC patients 29.3%.（22/75）（P<0.05）.The expression of AQP-1 was associated with lymph node metastasis in ESCC patients（P<0.05）.The positive rate of P57^kip2was33.3%（25/75）in ESCC,77.3%（58/75）in the normal tissue of the ESCC patients,There were significant differences（P<0.05）.There was a negative correlation between the expression of AQP1 and P57^kip2in ESCC.Conclusion The high expression of AQP1 and the low express of P57^kip2may be concerned with the genesis and the development of human ESCC.The combined detection of AQP1 and P57^kip2expression may be used in assessing the metasasis and predicting the clinical prognosis of ESCC.更多还原