【摘要】 [目的]探讨铅锌矿区职业人群体内锌、镉负荷及脂质过氧化物酶的含量。[方法]采用横断面流行病学研究方法,对146名某矿区作业工人和54名非矿区人群进行健康检查和现场采集发样及血样,检测其发镉、发锌、血镉、血锌及血清脂质过氧化酶超氧化物歧化酶(T-SOD)、丙二醛(MDA)及谷胱甘肽氧化酶(GSH-Px)的水平,并进行统计学分析。[结果]接触组发锌、发镉、血镉均高于对照组(P<0.01或P<0.05),血锌、T-SOD、GSH-Px活性均低于对照组(P<0.01或P<0.05);接触组MDA水平与对照组差异无统计学意义(P>0.05)。接触组中工龄≤10年者,其发镉及血镉水平均低于工龄11年以上者,差异有统计学意义(P<0.05)。[结论]铅锌矿区职业人群长期接触镉后可改变体内T-SOD、GSH-Px、MDA水平,导致矿区职业人群体内脂质过氧化作用增强,抗氧化能力降低。更多还原

【Abstract】 [Objective] To investigate the burdens of lead and cadmium and the content of lipid peroxide of occupational populations in a lead-zinc mining area. [Methods] A cross-sectional epidemiological design was used to carry out health examination and on-site collection of blood and hair samples among 146 workers in a lead-zinc mining area and 54 controls in a nonmining area. Hair cadmium, hair zinc, blood cadmium, blood zinc, and serum superoxide dismutase(T-SOD), malonyldialdehyde(MDA), and glutathione peroxidase(GSH-Px) were detected and analyzed. [Results] Compared with the control group, the exposure group reported higher levels of hair zinc, hair cadmium, and blood cadmium(P < 0.01 or P < 0.05) and lower levels of blood zinc, T-SOD, and GSH-Px(P < 0.01 or P < 0.05). No statistical difference was found in the MDA level between the two groups. The workers with service length ≤10 years showed lower levels of hair cadmium and blood cadmium than those of the worker with service length >11 years(P < 0.05). [Conclusion] Long-term exposure of the occupational population in the lead-zinc mining area to cadmium could significantly change the levels of T-SOD, MDA, and GSH-Px, enhance lipid peroxidation, and decline antioxidantion.更多还原