【摘要】 [目的]了解载脂蛋白AV(apoAV)-1131 T>C基因多态性和apoAV水平与非酒精性脂肪性肝病(NAFLD)的关系。[方法]对78例B超确诊为NAFLD患者(NAFLD组)和58例同期体检示非NAFLD者(对照组),采用酶联免疫吸附试验检测血清apoAV浓度进行测定,通过聚合酶联反应-限制性长度多态性方法进行apoAV-1131 T>C基因多态性分析。[结果]NAFLD组的apoAV水平低于对照组、TC基因型频率高于对照组(均P<0.05);TC+CC基因型的血清apoAV水平低于TT基因型、血清三酰甘油水平高于TT基因型(均P<0.05)。[结论]apoAV-1131 T>C位点影响血清apoAV和三酰甘油水平,增加了NAFLD的发病风险。更多还原

【Abstract】 [Objective]To detect the apolipoprotein AV(apoAV)-1131 T>C gene polymorphism and serum apoAV level in non-alcoholic fatty liver disease(NAFLD)patients and explore the relationship.[Methods]Serum apoAV concentration in seventy-eight cases of NAFLD diagnosed by ultrasound and fifty-eight cases of normal control was measured by using enzyme-linked immunosorbent assay.The apolipoprotein AV-1131 T>C gene polymorphism was detected by the polymerase reaction-limiting length polymorphism methods.[Results]ApoAV level of NAFLD group was obviously lower than normal group.TC genotype frequency in NAFLD group was significantly higher than normal group(P<0.05).TC/CC genotype of serum apoAV was significantly lower than TT genotype,TC/CC genotype of serum triglycerides level was higher than TT genotype.[Conclusion]apoAV-1131 T>C sites affect serum apoAV and TG levels,and increase the risk of NAFLD.更多还原