新辅助化疗联合手术治疗局部晚期食管癌的疗效分析

【摘要】 目的分析研究新辅助化疗联合手术治疗局部晚期食管癌的临床疗效。方法将52例ⅡA~Ⅲ期食管癌患者随机分为观察组30例和对照组22例。观察组给予依托泊苷(VP16)联合5-氟尿嘧啶(5-FU)、顺铂(DDP)治疗,化疗结束后4周行食管癌根治术。对照组患者仅给予单纯手术治疗。结果观察组6个月和1年生存率分别为93.33%、83.33%,对照组术后6个月和1年的生存率分别为81.82%、72.73%,两组间比较,差异有统计学意义(P<0.05);两组患者术前生存质量评分比较,差异无统计学意义(P>0.05),治疗后6个月、1年后观察组生存质量评分高于对照组(P<0.05)。结论新辅助化疗联合手术治疗局部晚期食管癌可以显著提高患者近期生存率、改善预后,值得推广应用。更多还原

【Abstract】 Objective Clinical therapeutic effect in the treatment of locally advanced esophageal carcinoma: analysis of neoadjuvant chemotherapy on the jointoperation. Methods 52 cases of esophageal cancer patients with stage III and II A~were randomly divided into the observation group 30 cases and control group with 22 cases. The observation group was given etoposide(VP16) combined with 5- fluorouracil(5-FU) and cisplatin(DDP) chemotherapy treatment, at 4 weeks afterradical operation of carcinoma of esophagus. The control group were only givensimple surgical treatment. Results In the observation group, 6 months and 1 year survival rates were 93.33%, 83.33%, the control group after 6 months and 1 yearsurvival rates were 81.82%, 72.73%, two the differences between groups was statistically significant(P<0.05); two patients were survival quality score group before compare difference not to have statistical significance(P>0.05), after 6 months of treatment, 1 years after the observation group quality of life scoreshigher than the control group(P<0.05). Conclusion Can significantly improve theshort-term survival rate and improve the prognosis in patients with neoadjuvantchemotherapy combined with surgery in the treatment of locally advancedesophageal carcinoma, and is worthy of popularization and application.更多还原