【摘要】 微小RNA(miRNAs)是一类具有调控功能的内源性非编码单链小分子RNA,长约18~24个核苷酸,与鼻咽癌(nasopharyngeal carcinoma,NPC)的发生发展、诊断以及预后、转归有关。BamH1 A右向转录(BamH1 A rightward transcripts,BARTs)是EB病毒(EBV)中一组经转录后选择性多剪接的基因产物,存在于EBV所有潜伏状态的miRNA,共22种(miR-BART1—22),并表达于NPC等EBV感染相关的恶性肿瘤。阐明miR-BARTs在NPC的作用机制对指导临床治疗有重要意义。更多还原

【Abstract】 MicroRNAs(miRNAs)are a class of endogenous small non-coding single-stranded18-24 nucleotide RNAs that play important roles in gene regulation.It has been reported that miRNAs play a vital role in the occurrence,development,diagnosis and prognosis of nasopharyngeal carcinoma(NPC).BamH1-A rightward transcripts(BARTs),including 22 viral miRNAs,are located in long alternative spliced Epstein-Barr virus(EBV)transcripts and expressed in EBV-associated malignant tumors.It is of great clinical significance to illuminate the mechanism of action of miR-BARTs in NPC.更多还原