【摘要】 目的 探讨认知行为治疗对产后抑郁症患者临床疗效及性激素水平的影响。方法 将80例产后抑郁症患者分为A组与B组,将40名健康产妇设为对照组;A组与B组分别予以认知行为治疗及抗抑郁药物治疗,观察8周。于治疗前后采用汉密顿抑郁量表、副反应量表评定临床疗效及不良反应,同时检测3组被试雌二醇、孕酮及泌乳素水平。结果 治疗8周末,A组痊愈率为63.2%,B组为65.8%,两组比较差异无显著性(P>0.05)。A组副反应量表的严重程度及痛苦感觉评分显著低于B组(P<0.01)。入组时A组B组雌二醇水平均显著低于对照组(P<0.01),孕酮水平显著高于对照组(P<0.01);研究8周末A组与B组雌二醇水平显著升高(P<0.01),孕酮水平显著降低(P<0.01),3组间比较差异无显著性(P>0.05),B组泌乳素水平显著低于A组及对照组(P<0.01)。结论 认知行为治疗对产后抑郁症患者有较好的疗效,无明显不良反应,有利于患者性激素水平恢复正常。更多还原

【Abstract】 Objective To explore the influences of cognitive behavior therapy(CBT)on curative effect and sexual hormone levels of postpartum depression(PD) patient.Methods Eighty PD patients were assigned to group A and B and 40 healthy parturients to control group;group A and B were treated with CBT and antidepressants for 8 weeks.Efficacies were assessed with the Hamilton Depression Scale(HAMD) before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale(TESS),estradiol,progesterone and lactotropin levels detected for 3 groups at the same time.Results At the end of 8week treatment cure rate was respectively 63.2%in group A and 65.8%in B,which showed no significant group difference(P>0.05).Severity and pain score of the TESS were significantly lower in group A than in B(P<0.01).At enrolment estradiol levels of both group A and B were significantly lower(P<0.01) and progesterone higher(P<0.01) compared with control group;at the end of 8 week treatment estradiol levels of both group A and B heightened significantly(P<0.01) and progesterone lowered(P<0.01).there were no significant differences among 3 groups(P>0.05),and prolactin levels were significantly lower in group B than in A and control group(P<0.01).Conclusion CBT is effective in postpartum depression,has no obvious adverse reactions,and is beneficial to the recovery of sexual hormone levels.更多还原