【摘要】 目的探讨直肠癌远端黏膜COX-2及BCL-2蛋白的表达情况以及术后随访结果,研判直肠癌手术远端安全切除范围。方法取54例直肠癌远端2cm及3cm黏膜,通过免疫组织化学(S-P法)的方法检测两组黏膜组织、肿瘤组织以及20例手术切除的直肠正常黏膜组织中COX-2蛋白和BCL-2蛋白的表达情况,同时所有病人术后随访3年。结果 54例直肠癌远端黏膜与肿瘤内BCL-2及COX-2蛋白的表达有显著差异(P<0.05),与直肠正常黏膜组织中COX-2蛋白和BCL-2蛋白的表达无差异(P>0.05)。所有54例病人术后无局部复发,10例远处转移。结论直肠癌肿远端切除2cm黏膜可以认为是安全切缘。更多还原

【Abstract】 Objective To detect the expression of COX-2 and BCL-2 protein in distal mucosa adjacent to rectal carcinoma, and to judge the surgical resection range for rectal cancer. Methods Immunohistochemical method was used to investigate the expression of BCL-2 and COX-2 protein in the specimen of rectal carcinoma mass, distal mucosa from the mass(54 cases), and normal rectal mucosa(20 cases). Results The expressions of COX-2 and BCL-2 protein can be detected in carcinoma mass and distal mucosa. There was significant between carcinoma mass and distal mucosa(P<0.05). Conclusion It is sufficient to resect distal mucosa 2cm away from the rectal carcinoma mass.更多还原