【摘要】 目的 探讨急性冠状动脉综合征(ACS)经皮冠状动脉介入治疗(PCI)术前与术后患者炎性标记物:白细胞介素-6受体(IL-6R)和金属肽酶含血小板反应蛋白基元-1(ADAMTS-1)及氧化型低密度脂蛋白(ox-LDL)水平的变化及意义。方法 选取ACS患者149例,其中急诊PGI急性心肌梗死(AMI)39例,PCI不稳定型心绞痛(UA)42例;非PCI患者AMI 32例,UA 36例。冠状动脉造影检查证实冠脉无狭窄对照组56例。所有研究对象入院时采静脉血,ACS入院12小时后再次采静脉血,应用酶联免疫吸附试验(ELISA)法检测外周血IL-6R、ADAMTS-1及ox-LDL水平。结果 入院时PCI AMI组、PCI UA组、AMI组及UA组IL-6R、ADAMTS-1及ox-LDL血清水平均高于对照组,差异有统计学意义(P<0.05)。入院时PCI AMI组及AMI组ox-LDL血清水平高于PCI UA组、UA组,差异有统计学意义(P<0.05)。入院12小时后PCI AMI组、:PCI UA组IL-6R、ADAMTS-1水平均较入院时升高,差异有统计学意义(P<0.05);而入院12小时后AMI组、UA组IL-6R、ADAMTS-1水平较入院时比较差异无统计学意义(P>0.05)。结论 IL-6R、ADAMTS-1是ACS炎症反应的重要标志,ACS经皮冠状动脉介入治疗术后炎症反应增加。更多还原

【Abstract】 Objective To investigate the changes and significance of inflammatory markers:interleukin 6 receptor(IL-6R),adisintegrin and metalloprotease with thrombospongdin type 1 motifs(ADAMTS-1),oxidized low density lipoprotein(ox-LDL) preoperative and postoperative of percutaneous coronary intervention(PCI) in patients of acute coronary syndrome(ACS).Methods 149 ACS patients were admitted,including 39 cases of acute myocardial infarction(AMI) and 42 unstable angina(UA) patients underwent PCI,32 cases of AMI and 36 UA patients without PCI.56 cases with no coronary artery stenosis were selected as a control group.Venous blood were collected at the time of admission,and will be collected again after 12 h in the ACS group,then detected the levels of IL-6R,ADAMTS-1 and ox-LDL of all the patients.Results The serum IL-6R,ADAMTS-1 and ox-LDL levels of group PCI-AMI,PCI-UA,no-PCI-AMI no-PCI-UA group were significantly higher than that of normal control group,the difference was statistically significant(P<0.05).The serum ox-LDL level of group PCI-AMI and no-PCI-AMI was significantly higher than that of PCI-UA and no-PCI-UA group(P<0.05);The serum IL-6R,ADAMTS-1in group PCI-AMI and PCI-UA after 12 h increased compared with preoperative,the difference was statistically significant(P<0.05).The serum IL-6R,ADAMTS-1 after 12 h had no statistical difference compared with the time of admission in group no-PCI-AMI and no-PCI-UA(P>0.05).Conclusion IL-6R and ADAMTS-1 are important symbols of inflammatory and the inflammatory levels increase after PCI in patients of ACS.更多还原