【摘要】 目的:探讨帕利哌酮与利培酮对精神分裂症首次发病患者血清催乳素水平(PRL)及体质量的影响。方法:130例首发精神分裂症患者随机分成帕利哌酮组66例(实际完成31例)和利培酮组64例(实际完成42例),分别给予帕利哌酮和利培酮治疗,观察12周。采用阳性与阴性症状量表(PANSS)在治疗前后进行测评;同时检测血清PRL及体质量,比较治疗前后的变化。结果:两组PANSS总分治疗后各周期均显著下降(P均<0.01),而血清PRL和体质量均较治疗前明显增加(P<0.05);两组间比较,差异无统计学意义。结论:帕利哌酮与利培酮治疗精神分裂症首次发病患者疗效相当,但两药均可致血清PRL及体质量增高。更多还原

【Abstract】 Objective: To explore the effect of paliperidone and risperidone on the serum prolactin level( PRL) and body mass in patients with the first episode of schizophrenia. Method: 130 cases of patients with first-episode schizophrenia were divided into 66 cases of paliperidone group( 31 cases actually completed) and64 cases of risperidone group( 42 cases actually completed). They were treated respectively with risperidone and paliperidone with 12 weeks of observation. The efficacy were assessed with the positive and negative symptoms scale( PANSS) before and after treatment,PRL and body mass were detected and the change were compared before and after treatment. Results: The total scores of the PANSS of the two groups were decreased significantly( all P < 0. 01). The PRL and body mass were increased significantly after treatment( P < 0. 05). The difference was not statistically significant between the two groups. Conclusion: Treatment efficacy of paliperidone in patients with first-episode schizophrenia is equivalent to risperidone,the two drugs both can cause PRL and body mass increased.更多还原