【摘要】 以樟脑酸和氨乙基取代苯基硫脲为原料,合成了10个新型的樟脑酸基硫脲类化合物(5a-5j)。利用FT-IR、1H NMR、13C NMR、LC-MS和元素分析等手段对目标产物进行了结构表征。同时对化合物5a-5j的抑菌活性进行了测试。初步的生物活性测试表明,在质量浓度为50 mg/L时,大部分化合物具有一定的抑菌活性,其中化合物樟脑酸基邻甲氧基苯基硫脲5c(R=o-CH3O)和樟脑酸基间甲氧基苯基硫脲5d(R=m-CH3O)对番茄早疫病菌(Alternaria solani)的抑制率达86.9%,化合物樟脑酸基间甲氧基苯基硫脲5d、樟脑酸基间甲基苯基硫脲5g(R=m-CH3)和樟脑酸基对溴苯基硫脲5i(R=p-Br)对苹果轮纹病菌(Physalospora piricola)的抑制率达86.1%。此外,化合物5i还对花生褐斑病毒(Cercospora arachidicola)具有最好的抑制率(73.6%)。更多还原

【Abstract】 Ten novel camphoric acid-based thiourea compounds( 5a-5j) were prepared using camphoric acid and aminoethyl substituted phenyl thioureas as starting materials. The target compounds werecharacterized by FT-IR,1H NMR,13 C NMR,LC-MS,and elemental analysis. The antifungal activities of the compounds 5a-5j were tested. The preliminary bioassay showed that most of the target compounds exhibited certain antifungal activities,in which camphoric acid-based( o-methoxy) phenyl thiourea 5c( R = o-CH3O) and camphoric acid-based( m-methoxy) phenyl thiourea 5d( R = m-CH3O) had inhibition rate of 86. 9 % against Alternaria solani,and camphoric acid-based( m-methoxy) phenyl thiourea5 d,camphoric acid-based( m-methyl) phenyl thiourea 5g( R = m-CH3) and camphoric acid-based( p-bromo) phenyl thiourea 4i( R = p-Br) had inhibition rate of 86. 1 % against Physalospora piricola at the concentration of 50 mg/L. In addition,compound 5i also had the best inhibitory activity against cercospora arachidicola( 73. 6%).更多还原