【摘要】 目的探讨不同程度肺挫伤中可溶性髓样细胞触发受体-1(sTREM-1)及肿瘤坏死因子-ɑ(TNF-ɑ)的动态表达变化及其临床意义。方法设立健康体检人群组(A组)为对照组。用定酶联免疫吸附试验(ELISA)法测定不同程度肺挫伤组中血清sTREM-1和TNF-ɑ含量在患者入院时及入院后1天、3天、7天的变化。结果肺挫伤时血清sTREM-1较A组明显升高(P<0.05);TNF-ɑ含量(除B组第七天)较A组明显升高(P<0.05);sTREM-1及TNF-α在肺挫伤早期均明显升高,肺挫伤伤情越严重则升高越明显,同时随着病情的好转而逐渐表达下降。结论 sTREM-1及TNF-α可推荐作为临床评估肺挫伤严重程度及预后的有效指标。更多还原

【Abstract】 Objective To study the dynamic changes of soluble triggering receptor expressed on myeloid cell-1( sTREM-1) and tumor necrosis factor-α( TNF-α) in different degrees of pulmonary contusion and its clinical significance. Methods The healthy people were selected as the control group. The levels of sTREM-1 and TNF-α in different degrees of pulmonary contusion and its changes on admission and 1,3 and 7 days after admission were detected by enzyme linked immunosorbent assay( ELISA) method. Results The serum sTREM-1 in pulmonary contusion increased obviously compared with the control group( P < 0. 05). The serum TNF-α content of lung contusion( except the seventh day in the group B) was significantly higher in the study group than in the control group( P <0. 05). The sTREM-1 and TNF-α increased significantly in early pulmonary contusion,and with the severity of pulmonary contusion. With the improvement of the disease,the levels of sTREM-1 and TNF-α decreased gradually.Conclusion TNF-α and sTREM-1 can be recommended as the effective index in evaluating the severity and prognosis of pulmonary contusion.更多还原