【摘要】 目的探讨痰热清注射液在绿脓杆菌肺部感染治疗中对血清细胞因子白介素-6和白介素-10的影响。方法对我院2013年1月~2014年3月ICU绿脓杆菌肺部感染患者随机分为对照组和治疗组,对照组给予常规治疗,治疗组给予常规联合痰热清注射液治疗。结果两组血清白介素-6水平均降低,且第10天治疗组低于对照组(P<0.05);两组白介素-10水平均升高,且第10天治疗组高于对照组(P<0.05)。治疗组的APACHEⅡ评分、SOFA评分下降较对照组更明显(P<0.05);且治疗组患者ICU住院天数、28天内抗生素使用天数、机械通气的天数均较对照组也显著下降(P<0.05)。结论痰热清注射液具有协同抗感染作用,对治疗绿脓杆菌肺部感染具有较好的疗效。更多还原

【Abstract】 Objective To investigate the effect of Tanreqing injection on serum IL-6 and IL-10 in the treatment of pseudomonas aeruginosa lung infection in ICU. Methods Patients with pseudomonas aeruginosa pneumonia were randomly divided into the treatment group and the control group. All patients were treated with conventional therapy,and the treatment group was given Tanreqing injection. Results The serum IL-6 level in the two groups descended after the treatment,and it was lower in the treatment group than in the control group 10 days after the treatment( P < 0. 05). The serum IL-10 level increased in the two groups,but increase was more pronounced in the treatment group than in the control group 10 days after the treatment( P < 0. 05). The scores of APACHE Ⅱ and SOFA decreased more significantly in the treatment group than in the control group( P < 0. 05). The duration of ICU stay,antibiotic use within 28 days and days of mechanical ventilation were significantly shorter in the treatment group than in the control group( P < 0. 05). Conclusion Tanreqing injection has synergistic anti-infection effect,which is effective in the treatment of pseudomonas aeruginosa pneumonia.更多还原