Objective To investigate the expression of runt-related transcription factor 3(RUNX3)protein in esophageal squamous cell carcinoma(ESCC).Methods Immunohistochemistry(IHC)SP method was used to detect the expression of runt-related transcription factor 3(RUNX3)protein in 20 cases of normal esophageal mucosa and 48 cases of ESCC tissues.Results The positive rate of RUNX3 in ESCC tissues was 37.5%(18/48),significantly lower than that in normal esophageal mucosa 80.0%(16/20)(P <0.05).The expression of RUNX3 had ...