【摘要】 目的:探讨米氮平合并喹硫平治疗老年抑郁症的疗效及安全性。方法:将40例老年抑郁症患者根据随机分为研究组(米氮平并喹硫平)20例和对照组(单用米氮平)20例,疗程8周。于治疗前及治疗后第2、4、6、8wk末应用汉密尔顿抑郁量表(HAMD),副反应量表(TESS)分别评定疗效和治疗中出现的副反应。结果:治疗后第4、6、8周末,研究组HAMD评分较治疗前均显著降低(P<0.05);治疗后第6、8周末,对照组HAMD评分较治疗前均显著降低(P<0.05);治疗后第4、6、8周末,研究组的HAMD评分均低于对照组(P<0.05)。研究组、对照组的有效率分别为80%、45%,两组之间疗效有显著性差异(P<0.05);两组不良反应比较差异无显著性(P>0.05)。结论:米氮平合并喹硫平治疗老年抑郁症安全有效。更多还原

【Abstract】 Objective: To explore the curative effect and safety in the treatment of senile depression by using the combination of mirtazapine and quetiapine. Methods: A total of 40 patients with senile depression were randomly divided into study group( 20 cases) treated by mirtazapine combining with quetiapine,and control group( 20 cases) treated by mirtazapine for 8 weeks. The efficacy and side effects were evaluated by Hamilton Depression Rating Scale( HAMD) and Treatment Emergent Symptom Scale( TESS) at the 2nd,4th,6th,8th weekend before and after treatment. Results: The scores of HAMD in study group decreased significantly compared with that before treatment at the end of wk4,6 and 8( P < 0. 05); The scores of HAMD in control group decreased significantly compared with that before treatment at the end of wk 6 and 8( P < 0. 05); Scores of HAMD in study group were significantly lower than that in control group at the end of wk4,6 and 8( P < 0. 05). There was significant difference in effective power between study group and control group( 80% vs. 45%,P < 0. 05). There was no significant difference in side effects between two groups( P > 0. 05). Conclusion: Mirtazapine combining with quetiapine is safe and effective in the treatment of patients with senile depression.更多还原