【摘要】 目的:评价拔牙后牙槽窝内填塞Bio-oss人工骨对延期种植骨结合的影响,为临床提供实验依据。方法:全麻下拔除6只杂种犬双侧下颌第三、四前磨牙,随机选取两个拔牙窝作为实验组,牙槽窝内填塞Bio-oss人工骨粉并覆盖钛膜;另外两个拔牙窝不作任何处理作为对照组。术后3个在植入种植体,Golden’s三色法观察种植体周围骨结合。结果:实验组及对照组种植体周围新骨均生成良好,实验组3个月可见Bio-oss颗粒;种植体植入术后3个月实验组的骨-种植体接触率及种植体周围骨面积均显著高于对照组,差异有统计学意义(P<0.05)。种植体植入术后6个月实验组的骨-种植体接触率及种植体周围骨面积略高于对照组,但差异无统计学意义。结论:拔牙窝内填塞Bio-oss人工骨有利于延期种植骨结合。更多还原

【Abstract】 Objective:To evaluate the influence on the osseointegration of delayed implantation of dental implant with Bio-Oss artificial bone following tooth extraction.Methods:The bilateral 3rd and 4th mandibular premolars of6 adult,healthy,male and female dogs were extracted.We randomly selected 2extraction sockets in each dog to be filled with Bio-Oss(the experimental group);the other 2extraction sockets which were not treated served as the control group.Dental implants were inserted into the alveolar bone of the experimental group and the control group3 months after Bio-Oss placement.The osteogenic activity in the bone around the implants was assessed by evaluating the histological morphology and estimating histomorphometric parameters 3and 6months after delayed implantation.Results:After the 3 months,Goldner’s trichrome staining analysis showed that the bone-implant contact rate and mineralized bone area around the implant were significantly higher in the experimental group(75.98%±8.97% and 69.52% ±9.63%,respectively)than those in the control group(56.13% ±8.18% and 52.82% ±7.25%,respectively,P<0.05).However,no significant difference was found between the 2groups after 6months.Conclusion:These data indicate that alveolar ridge preservation by using Bio-Oss placement can promote osseointegration of delayed implantation,and may be a promising option for clinical use.更多还原