【摘要】 目的观察一种空间维持装置进行上颌窦骨增量术后新骨形成情况,并探究上颌窦黏膜穿孔对该技术的影响。方法采用纯钛制作上颌窦黏膜提升空间维持装置,3只比格犬拔除上颌后牙构建上颌后牙缺失上颌窦区骨量不足的动物模型,自然愈合3个月后行双侧的上颌窦黏膜提升,随机选取一侧在黏膜完整情况下放入空间维持装置,对侧在黏膜穿孔情况下放入空间维持装置。3个月后处死实验动物,制取标本进行组织学分析。结果空间维持装置内部可见新骨呈帽状凸起,与提升空间的形态相适应,但尚未充满整个提升的空间,窦底骨与新骨之间界限明显,新骨为未成熟的编织骨,疏松排列的骨小梁交错成网,骨小梁内可见软骨陷窝分布;无骨粉充填的上颌窦骨增量术在黏膜完整、穿孔后新骨面积分别为(8.17±5.63)mm2,(9.92±4.65)mm2,差异没有统计学意义。结论单纯利用空间维持装置进行的上颌窦骨增量术可以诱导新骨形成,且较小的黏膜穿孔对其没有影响,具体新骨形成机制仍有待探索。更多还原

【Abstract】 Objective To evaluate the quantity of new bone formation through maxillary sinus bone augmentation using space maintaining device and to assess the influence of perforation on it. Methods Space maintaining devices were made by pure titanium to keep the elevated space. Three adult male beagle dogs were subjected to extraction of the third premolar and all molars of both sides to create a model with bone volume deficiency in the maxillary posterior region. After the natural healing 3 months later,space maintaining devices were installed simultaneously with the elevation of maxillary sinus membrane using the lateral approach without the use of bone substitutes. A perforation of 2 mm in diameter was randomly created in one side. Three animals were sacrificed 3 months after the surgery. Results The histological examination of the specimens showed bone formation was found underneath the space maintaining device but didn’t fill the space. The shape of new bone was in accord with the outline of the elevated membrane. The newly formed bone was immature woven bone and composed of trabecular bone structure. New bone area was( 8. 17 ± 5. 63) mm2and( 9. 92 ± 4. 65) mm2 respectively in the condition of membrane intactness and perforation. The difference was not significant. Conclusions New bone formation can be found in nongrafted maxillary sinus bone augmentation using space maintaining device and the small perforation has no effect on it. The mechanism of new bone formation remains to be explored.更多还原