Objective: OSCC is associated with poor prognosis,which has improved only marginally over the past three decades. A proteomic analysis of OSCC lesions may help identify novel molecular targets for the early detection,prevention,and treatment of it.Methods: Laser capture microdissection was combined with recently developed techniques for protein extraction from formalin-fixed paraffin-embedded( FFPE) tissues and a novel proteomics platform. Approximately 10,000 cells procured from FFPE tissue sections of nor...
【基金】
国家自然科学基金国际合作交流中加项目(81010066)
【更新日期】
2016-01-21
【分类号】
R739.8
【正文快照】
!头颈部鳞状细胞癌(squamous cell carcinoma ofthe head and neck,HNSCC)是最常见的十大肿瘤之一,其中口腔鳞状细胞癌(oral squamous cell carcino-ma,OSCC)约占HNSCC的55%。虽然近30年来肿瘤分子机制的研究不断深入,治疗手段不断丰富,但是HNSCC,包括OSCC的5年生存率并没有显?
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