【摘要】 目的了解钛涂层、羟基磷灰石(hydroxyapatite,HA)涂层和钛+HA复合涂层螺钉置入体内后早期的生物力学稳定性。方法选取成年比格犬32只平均分为4组:普通螺钉对照组(对照组)、HA涂层螺钉组(HA组)、钛涂层螺钉组(钛组)、钛+HA复合涂层螺钉组(复合组)。每组4只用该组相应螺钉固定于C2~7作为无应力螺钉测试组(无应力组),共测试32枚螺钉,其中16枚螺钉作旋出扭矩测试,16枚螺钉作拔出力测试。记录旋出扭矩峰值、拔出力峰值和拔出能量。每组另4只作C4/C5椎间融合后采用该组螺钉+钛板固定于C4,5椎体上作为应力螺钉测试组(应力组)。每组16枚螺钉作抗拔出力测试。记录螺钉的拔出力峰值和拔出能量。结果在应力及非应力条件下,各组螺钉旋出扭矩峰值、拔出力峰值、断裂能量比较,HA组>复合组>钛组>对照组。结论螺钉表面涂层能提高螺钉-骨组织界面的结合力。HA涂层螺钉的生物力学稳定性最好,钛涂层+HA复合涂层其次,提示HA的生物活性在置入早期可能对螺钉的生物力学稳定性起重要作用。更多还原

【Abstract】 Objective To investigate the biomechanical stability of titanium coating screw,hydroxyapatite( HA) coating screw,and titanium + HA coating screw at 3 month after implantation in vivo study. Methods The 32 beagle dogs were divided into 4 groups: normal screws group( Control group),HA coating screw group( HA group),Titanium coating screw group( Titanium group),Titanium + HA coating screw group( Titanium + HA group). The designated screws were implanted in the cervical vertebra( C2-7) of beagle dogs in every 4 dogs in each group as non-stress group. Extraction torque tests were carried out in 16 out of 32 screws. The pull-out resistance tests were carried out in the other 16 screws. The peak torque and the peak pull-out resistance were recorded. The other 4 dogs were designated as stress-group,anterior cervical fusion were performed at the C4/ C5 level,screws were incerted with anterior plated at the C4,5. The pull-out resistance tests were carried out in the these 16 screws. The peak pull-out resistance and energy were recorded. Results In both stress group and nonstress group,the peak torque,the peak pull-out resistance and energy were compared,HA group > Titanium + HA group >Titanium group > Control group. Conclusion The HA coating screw has the best biomechanical results at 3 months after implantation in vivo study.更多还原