【摘要】 目的探讨2型糖尿病(T2DM)患者血清游离脂肪酸(FFA)水平与胰岛素抵抗的相关性。方法选取102例T2DM患者作为T2DM组,依据糖化血红蛋白(HbA1c)水平分为控制良好和控制不良组,选取62例健康体检者作为健康对照组,检测各组的HbA1c、三酰甘油(TG)、空腹血糖(FBS)、餐后2h血糖(PPBS)、空腹胰岛素(FINS)、空腹FFA及餐后2h游离脂肪酸(2hFFA)。以稳态模式评估胰岛素抵抗指数(HOMA-IR)。结果T2DM组HbA1c、TG、FBS、PPBS、FFA、2hFFA及HOMA-IR均较健康对照组明显升高(P<0.05)。T2DM控制不良组各指标均高于控制良好组(P<0.05)。FFA、2hFFA与其他指标均呈明显正相关(r>0.5,P<0.01)。结论T2DM患者体内FFA水平显著升高,与胰岛素抵抗存在明显相关性。更多还原

【Abstract】 Objective To investigate the relationship of serum free fatty acid(FFA)level and insulin resistance in patients with type 2diabetes mellitus(T2DM).Methods A total of 102 T2 DM patients were enrolled(T2DM group),and divided into well-control group and poor-control group according to their glycosylated hemoglobin(HbA1c)levels.Moreover,62 healthy people were recruited as normal control group.All of the subjects were underwent measurement of triglyceride(TG),HbA1 c,fast blood glucose(FBS),2 h postprandial blood glucose(PPBS),fast insulin(FINS),fast FFA and 2hpostprandial FFA(2hFFA).And the insulin resistance index(HOMA-IR)was evaluated by homeostasis model.Results The levels of HbA1 c,TG,FBS,PPBS,FFA,2hFFA and HOMA-IR in T2 DM group were significantly higher than those in normal control group(P<0.05).And these parameters in poor-control group were higher than those in well-control group(P<0.05).FFA and 2hFFA were positively correlated with other parameters(r>0.5,P<0.01).Conclusion The serum level of FFA increased in T2 DM patients,which related with insulin resistance.更多还原