【摘要】 目的探讨血清同型半胱氨酸(Hcy)与胱抑素C(CysC)在妊娠高血压综合征(PIH)患者中的变化及临床价值。方法选取2010年10月至2014年6月夏津县人民医院收治的PIH患者118例,其中轻度32例,中度49例,重度37例。另取同期正常妊娠的孕妇55例作为对照组。分别采用循环酶法与胶体金免疫比浊法对患者组与对照组血清Hcy及CysC水平进行检测。结果对照组、轻度PIH组、中度PIH组及重度PIH组收缩压分别为(122.38±10.29)、(154.32±12.11)、(177.19±14.29)、(188.37±15.49)mm Hg,收缩压水平比较,差异有统计学意义(P<0.05);患者组血清Hcy与CysC水平均明显高于对照组,且重度PIH组血清Hcy及CysC水平也均明显高于轻度与中度PIH组,差异有统计学意义(P<0.05);患者血清Hcy及CysC与血压呈正相关(r>0,P<0.05)。结论血清Hcy与CysC水平与患者收缩压呈正相关,对PIH的临床诊断具有较高的价值。更多还原

【Abstract】 Objective To investigate the changes and clinical value of serum homocysteine(Hcy)and cystatin C(CysC)in pregnancy induced hypertension(PIH).Methods The clinical data of 118 patients with PIH in our hospital from October 2010 to June 2014 were retrospectively analyzed,including 32 cases of mild PIH,49 cases of moderate PIH and 37 cases of severe PIH.In addition,55 normal pregnant women during the same period were selected as the control group.The enzymatic cycling method and the colloidal gold immune turbidimetry were adopted to detect the serum Hcy and CysC levels and the detecting results were compared between the two groups.Results The systolic blood pressure in the control group,mild PIH group,moderate PIH group and severe PIH group were(122.38±10.29),(154.32±12.11),(177.19±14.29),(188.37±15.49)mm Hg respectively,the differences among the above groups were statistically significant(P<0.05);the levels of serum Hcy and CysC in the PIH groups were all significantly higher than those in the control group(P<0.05),moreover which in the severe PIH group were significantly higher than those in the mild and moderate PIH groups,the differences were statistically significant(P<0.05);the positive correlation existed between the levels of Hcy and CysC with blood pressure(r>0,P<0.05).Conclusion The serum Hcy and CysC levels are positively correlated with the systolic blood pressure,which has the higher value for the clinical diagnosis of PIH.更多还原