【摘要】 目的探讨二氯乙酸二异丙胺治疗结核药物所致肝损伤的疗效。方法将140例抗结核药物所致肝损伤患者随机分为治疗组与对照组,每组各70例患者。对照组给予常规保肝对症治疗,治疗组给予二氯乙酸二异丙胺治疗,疗程均为1个月。另纳入接受抗结核药物治疗但未发生肝损伤的患者140例。采用统计学方法分析抗结核药物所致肝损伤的危险因素,以及不同治疗方法对肝损伤患者血脂及肝功能指标的影响。结果非条件Logistic回归模型分析结果显示,年龄、营养状态、用药剂量和饮酒是抗结核药物所致肝损伤的独立危险因素(P<0.05)。治疗组治疗总有效率为97.1%,明显高于对照组的84.3%(P<0.05)。治疗后两组患者血清总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白水平明显升高,天门冬氨酸氨基转移酶、丙氨酸氨基转移酶及碱性磷酸酶水平明显降低(P<0.05);治疗后治疗组上述指标检测结果与对照组比较差异均有统计学意义(P<0.05)。结论二氯乙酸二异丙胺治疗抗结核药物所致肝损伤,可促进肝功能与血脂代谢的恢复,从而改善患者的预后。更多还原

【Abstract】 Objective To investigate the efficacy of diisopropylamine dichloroacetate in the treatment of antituberculosis drugs-induced liver injury.Methods A total of 140 antituberculosis drugs-induced liver injury patients were randomly divided into treatment group and control group,with 70 cases in each group.Control group were given conventional symptomatic treatment,and treatment group were given diisopropylamine dichloroacetate treatment method,treatment period of which were both one month.Another 140 patients treated with antituberculosis drugs,but without liver injury,were also enrolled.Risk factors of liver injury,changes of blood lipids and liver function parameters were statistically analyzed.Results Logistic regression model analysis showed that age,nutritional status,medication dosage and drinking were independent risk factors of antituberculosis drugs-induced liver injury(P<0.05).The effective rate of treatment group was 97.1%,higher than the 84.3% of control group(P<0.05).After treatment,serum levels of total cholesterol,triacylglycerol,high density lipoprotein and low density lipoprotein were increased significantly in both groups,but serum levels of aspartate aminotransferase,alanine aminotransferase and alkaline phosphatase were significantly decreased(P<0.05).After treatment,serum levels of parameters,mentioned above,of treatment group were statistically different with those of control group(P<0.05).Conclusion Diisopropylamine dichloroacetate could promote the recovery of liver function and lipid metabolism,thus improve outcomes of patients with antituberculosis drugs-induced liver injury.更多还原