【摘要】 The covalent attachment of O-linked b-Nacetylglucosamine(O-Glc NAc) to Ser/Thr residues of proteins acts as not only a posttranslational modification but also a nutritional sensor in nucleus and cytoplasm,which directly regulates the expression of genes and multiple crucial signal transduction pathways. Dynamic OGlc NAcylation at Ser/Thr residues is catalyzed by two key enzymes, O-Glc NAc transferase(OGT) and O-Glc NAcase,which are responsible for addition and removal of the OGlc NAc modification, respectively. O-Glc NAc modification plays important roles in cellular signaling in animals,especially in human diseases. Two orthologs of OGT in plants, SECRET AGENT and SPINDLY, have been reported to be involved in diverse plant processes. However, compared with the functional mechanisms revealed in animals, the consequences of protein O-Glc NAc modification in plants is largely unknown, and the relationship between O-Glc NAcylation and cellular processes needs to be explored. In this review, we summarized the recent advances on O-Glc NAc modification and its biological functions in animals and plants, and prospect of more special functions of O-Glc NAc will be revealed in plants.更多还原

【Abstract】 The covalent attachment of O-linked b-Nacetylglucosamine(O-Glc NAc) to Ser/Thr residues of proteins acts as not only a posttranslational modification but also a nutritional sensor in nucleus and cytoplasm,which directly regulates the expression of genes and multiple crucial signal transduction pathways. Dynamic OGlc NAcylation at Ser/Thr residues is catalyzed by two key enzymes, O-Glc NAc transferase(OGT) and O-Glc NAcase,which are responsible for addition and removal of the OGlc NAc modification, respectively. O-Glc NAc modification plays important roles in cellular signaling in animals,especially in human diseases. Two orthologs of OGT in plants, SECRET AGENT and SPINDLY, have been reported to be involved in diverse plant processes. However, compared with the functional mechanisms revealed in animals, the consequences of protein O-Glc NAc modification in plants is largely unknown, and the relationship between O-Glc NAcylation and cellular processes needs to be explored. In this review, we summarized the recent advances on O-Glc NAc modification and its biological functions in animals and plants, and prospect of more special functions of O-Glc NAc will be revealed in plants.更多还原