【摘要】 目的探讨吸烟与饮酒及其交互作用对肺癌发病的影响。方法在肿瘤高发地区开展以人群为基础的病例对照研究,通过调查问卷收集主要人口学、吸烟和饮酒等相关信息,采用非条件logistic回归分析计算比值比(OR)及95%CI,并分析吸烟与饮酒在肺癌发病中的交互作用。结果调整相关因素(包括饮酒)后,与不吸烟者相比,吸烟者患肺癌的风险增加(P<0.05),吸烟≥40年者患肺癌的风险是不吸烟者的4.79倍,每日吸烟≥20支者患肺癌的风险是不吸烟者的4.44倍,吸烟至肺部者患肺癌风险是不吸烟者的4.44倍(P值均<0.001)。调整变量(包括吸烟)后,饮酒和饮酒年限与肺癌发病之间无统计学关联(P>0.05)。吸烟和饮酒相乘交互作用的OR值(95%CI)为0.90(0.47~1.70)。吸烟和饮酒相加交互作用的超额相对危险度(RERI)值及其95%CI为0.36(-0.92~1.64),交互作用归因比(AP)值及95%CI为0.09(-0.22~0.40),交互作用指数(SI)值及95%CI为1.13(0.71~1.80)。结论吸烟是肺癌发病的主要危险因素,且该风险随吸烟年限、吸烟量、吸烟深度的增加而显著增加,现有证据并不支持饮酒与肺癌发病之间存在关联,吸烟和饮酒在肺癌发病中也未见交互作用。更多还原

【Abstract】 Objective To investigate relationship between cigarette smoking,alcohol drinking and their interaction with lung cancer.Methods A population-based case-control study was conducted in a high cancer risk area.Demographic information,cigarette smoking and alcohol drinking status of subjects were collected by questionnaire based survey.Unconditional logistic regression analysis was used to calculate odds ratio(OR)and 95%CI.Interaction between cigarette smoking and alcohol drinking in relation with lung cancer was further analyzed.Results Upon adjustment of variables(including factor of drinking),the risk of lung cancer among smokers was higher than non-smokers;the risk of smokers smoking for≥40years was4.79 times of that of non-smokers;the risk of lung cancer for smokers who had daily intake of≥20cigarettes and who sucked smoke into lung was 4.44 times of that of non-smokers(all P<0.001).Alcohol drinking and duration of drinking had no relationship with lung cancer after adjustment for cigarette smoking(P>0.05).Interaction between cigarette smoking and alcohol drinking was not related with lung cancer(OR=0.90,95%CI:0.47-1.70;RERI=0.36,95%CI:-0.92-1.64;AP=0.09,95%CI:-0.22-0.40;SI=1.13,95%CI:0.71-1.80).Conclusion Cigarette smoking was major risk factor for development of lung cancer;the lung cancer risk of smokers increased with duration,daily intake amount and depth of smoking.Relationship between alcohol drinking and lung cancer was not supported by current evidences.No interaction was found between smoking and drinking on risk for lung cancer.更多还原