【摘要】 目的分析南京市2010-2013年疑似预防接种异常反应(AEFI)的发生特征,评价预防接种的安全性和AEFI监测系统运转情况。方法通过AEFI信息管理系统及月报表,收集南京市2010-2013年报告的AEFI个案数据,采用描述流行病学方法进行分析。结果 2010-2013年南京市共报告AEFI 2 819例,报告发生率为39.30/10万剂。报告数居前3位的的疫苗分别是百白破(无细胞)844例(占29.94%),发生率为74.86/10万剂;白破364例(占12.27%),发生率为155.08/10万剂;麻风二联210例(占7.45%),发生率为255.15/10万剂。≤1岁1 086例(占38.52%);一般反应2 441例(占86.59%,其中以发热/红肿/硬结最多,占一般反应的95.08%),异常反应317例(占11.25%,其中以过敏性皮疹最多,占异常反应的82.83%),偶合症59例(占2.09%),心因性反应2例(占0.07%)。发生在接种后1d内的AEFI占81.59%;48h内报告率及调查率为100.00%。结论南京市AEFI监测系统运转正常,但监测系统的敏感性仍需提高,应继续加强各级医疗机构人员AEFI诊断、分类及处理等方面的培训。更多还原

【Abstract】 Objective to analyze characteristics of adverse events following immunization(AEFI)in Nanjing from 2010to2013;to evaluate immunization safety and performance of AEFI surveillance system.Methods AEFI data from 2010 to 2013of Nanjing was collected through AEFI information system and AEFI monthly report,which was analyzed by descriptive epidemiological method.Results From 2010 to 2013,a total of 2 819 AEFI cases were reported,resulting incidence of 39.30/105.Vaccines of top 3AEFI cases were Dtap,TD,and MR.A total of 844 cases were reported after Dtap vaccination,resulting incidence of 74.86/105,accounting for 29.94% of all AEFI cases.For TD and MR,the reported case numbers was 364 and 210,incidence was 155.08/105 and 255.15/105,accounting for 12.27%and 7.45% of all AEFI cases,respectively.Cases of vaccinated subject≤ 1year old accounted for 38.52%(1 086cases).2 441 cases were common reactions(accounted for86.59% of all AEFI cases,mainly were fever/inflammation/calluses,which accounted for 95.08% of all common reactions).317 cases were rare reactions(accounted for 11.25% of all AEFI cases,mainly were anaphylactic rash,which accounted for82.83% of all rare reactions).59 cases were coincidental events(accounted for 2.09% of all AEFI cases).2cases were psychogenic reaction(accounted for 0.07% of all AEFI cases).81.59% of AEFI occurred within ld after vaccination.All cases were reported and investigated within 48 h.Conclusion AEFI information system performed well in Nanjing,However,sensitivity of AEFI surveillance system needed to be improved.Training of AEFI diagnosis,classification and treatment among medical staffs should be strengthened.更多还原