【摘要】 以商品化的(1S,5R,6R,7R)-7-苯甲酰氧基-6-[3(S)-3-羟基-5-苯基-1(E)-戊基]-2-氧杂双环[3.3.0]辛烷-3-酮为原料,经4步反应合成一种四氢呋喃(THP)保护的拉坦前列素内半缩醛,并用核磁共振氢谱(1 H NMR)、核磁共振碳谱(13 C NMR)、红外光谱(IR)和质谱(MS)对产物进行表征.结果表明,终产物的收率为65.7%,纯度为99.0%.更多还原

【Abstract】 We reported a novel method for the synthesis of lactol from(1S,5R,6R,7R)-7-benzoyloxy-6-[3(S)-3-hydroxy-5-phenyl-1(E)-pentenyl]-2-oxabicyclo[3.3.0]octan-3-one in four steps.The product,with an overall yield of 65.7% and a purity of 99.0%,was characterized by 1 H NMR,13 C NMR,IR and MS.更多还原