【摘要】 目的 :利用DTI技术定量分析不同年龄段正常前列腺外周带(peripheral zone,PZ)和中央腺区(central zone,CZ)各向异性值(fractioanl anisotropy,FA)和ADC值,研究其随年龄的演变规律,利于前列腺疾病早期发现和诊断。方法:50名志愿者根据年龄分为3组,A组14例15~30岁,B组24例31~50岁,C组12例≥51岁,分别测量和分析不同年龄段正常前列腺PZ和CZ的FA和ADC值的差异。结果 :各年龄段PZ左右叶FA值、ADC值差异均无统计学意义(均P>0.05)。各年龄段PZ的FA值均低于CZ,PZ的ADC值均高于CZ(均P<0.05)。PZ的FA值及ADC值不同年龄段差异均有统计学意义(均P<0.05)。CZ的FA值及ADC值不同年龄段的差异均无统计学意义(均P>0.05)。Pearson相关分析结果显示PZ的FA值与年龄呈负相关(r=-0.498,P<0.05),ADC值与年龄呈正相关(r=0.682,P<0.05),CZ的FA值和ADC值变化与年龄均无明显相关性(均P>0.05)。结论 :DTI定量分析能够反映前列腺随年龄变化的差异,为前列腺疾病的早期发现和诊断提供参考依据。更多还原

【Abstract】 Objective:The focus of this study was to quantify age-related changes of fractional anisotropy（FA） and apparent diffusion coefficient（ADC） in the normal prostate peripheral zone（PZ） and central zone（CZ） using MR diffusion tensor imaging（DTI）. Then,to establish the normal reference range,which would help early detection and diagnosis of prostate disease.Methods:50 healthy volunteers were divided into 3 groups according to different age:group A（15³0 years,n=14）,group B（31⁵0 years,n=24）,group C（>51 years,n=12）. The FA and ADC values of PZ and CZ were measured. Difference between parameters of the PZ and CZ were assessed. Results:There was no significant difference of the FA and ADC values between the left and right of PZ（P> 0.05）. There were significant differences of the FA and ADC values on PZ and CZ in each group（P< 0.05）. The FA and ADC values on PZ in different age groups were（0.227 ±0.052）,（0.202 ±0.055）,（0.145 ±0.034）;（1.439±0.160）×10^-3mm²/s,（1.652±0.256）×10-3mm²/s,（2.001 ±0.266）×10-3mm²/s,respectively. There were significant differences of FA and ADC values on PZ between these groups（P< 0.05）. The FA and ADC values on CZ in different age groups were0.291±0.08,0.287±0.045,0.257±0.059;（1.374±0.171）×10^-3mm²/s,（1.382±0.178）×10^-3mm²/s,（1.415±0.136）×10^-3mm²/s,respectively. There was no significant difference of FA and ADC values on CZ among these groups（P> 0.05）. Pearson analysis suggested that the FA values on PZ were negative correlation with ages（r=-0.498,P< 0.05）,and the ADC values on PZ were positive correlation with ages（r=0.682,P< 0.05）. There was no correlation between the changes of FA and ADC values and age on CZ. Conclusion:DTI quantitative measurement can reflect age-related changes of normal prostate. The normal reference range is established,which provide reference for early detection and diagnosis of prostate disease.更多还原