Synthesis,Crystal Structure and in vitro Anticancer Studies of 1,2-Bis-benzimidazole-phenyl Copper(Ⅱ) Complex

【摘要】 One new benzimidazole derivative copper(II) complex 1(C10H6Cu N2, Mr = 217.71) has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a = 17.417(2), b = 8.9963(8), c = 11.3432(9) ?, V = 1777.3(3) ?3, Z = 8, μ(Mo Kα) = 2.403, F(000) = 872, Dc = 1.627 g/cm3. The final R = 0.0598 for 1153 observed reflections with I > 2σ(I) and w R = 0.17 for all data. The in vitro anti-cancer activities of 1, Cu Cl2 and the benzimidazole ligand L were investigated using human cervical(Hela) and hepatocellular carcinoma(Hep-G2) cancer cell lines. The copper(II) complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper(II) salt.更多还原

【Abstract】 One new benzimidazole derivative copper(II) complex 1(C10H6Cu N2, Mr = 217.71) has been synthesized and characterized by FT-IR and X-ray single-crystal diffraction. It crystallizes in orthorhombic, space group Pbcn with a = 17.417(2), b = 8.9963(8), c = 11.3432(9) ?, V = 1777.3(3) ?3, Z = 8, μ(Mo Kα) = 2.403, F(000) = 872, Dc = 1.627 g/cm3. The final R = 0.0598 for 1153 observed reflections with I > 2σ(I) and w R = 0.17 for all data. The in vitro anti-cancer activities of 1, Cu Cl2 and the benzimidazole ligand L were investigated using human cervical(Hela) and hepatocellular carcinoma(Hep-G2) cancer cell lines. The copper(II) complex can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both the ligand and copper(II) salt.更多还原