【摘要】 目的探讨静息态功能核磁共振成像(rs-fMRI)分数低频振幅(fALFF)和局域一致性(ReHo)方法在低氧暴露后飞行员静息态脑功能评价中的应用价值。方法 30名男性健康飞行员先后接受常压常氧、氧浓度为14.5%的常压低氧暴露,采用f ALFF及ReHo方法对受试者低氧暴露前后rs-f MRI数据进行对比分析,观察低氧暴露之后f ALFF及ReHo值发生变化的脑区。结果低氧暴露后,30名飞行员脉搏、血氧饱和度分别为64.0±10.6次/min、92.4%±3.9%,较暴露前(分别为71.4±10.9次/min、96.3%±1.3%)有所下降(P<0.05)。静息态下,30名飞行员低氧暴露后f ALFF值降低的脑区包括双侧颞上回、右侧额上回,f ALFF值增高的脑区为左侧楔前叶,Re Ho值降低的脑区为右侧额上回(P<0.05),未发现Re Ho值增加的脑区。结论低氧暴露对静息态下某些脑区功能活动有明显影响,可能与认知功能变化有关。更多还原

【Abstract】 Objective The objective of this study was to evaluate the basic changes in brain activity of pilots after hypoxic exposure with the use of resting-state functional magnetic resonance imaging(rs-f MRI) and regional homogeneity(Re Ho) method. Methods Thirty healthy male pilots were successively subjected to normal and hypoxic exposure(with an oxygen concentration of 14.5%). Both the f ALFF and Re Ho methods were adopted to analyze the resting-state functional MRI data before and after hypoxic exposure of the subjects, the areas of the brain with f ALFF and Re Ho changes after hypoxic exposure were observed. ResultsAfter hypoxic exposure, the pulse was 64.0±10.6 beats/min, and the oxygen saturation was 92.4%±3.9% in these 30 pilots, and it was lower than those before exposure(71.4±10.9 beats/min, 96.3%±1.3%, P<0.05). Compared with the condition before hypoxic exposure, the f ALFF value was decreased in superior temporal gyri on both sides and the right superior frontal gyrus, and increase in the left precuneus, while the value of Re Ho was decreased in the right superior frontal gyrus(P<0.05). No brain area with an increase in Re Ho value was found. Conclusions Hypoxic exposure could significantly affect the brain functions of pilots, which may contribute to change in their cognitive ability.更多还原