【摘要】 非酒精性脂肪性肝炎(NASH)是非酒精性脂肪性肝病(NAFLD)的最重要形式,可发展为肝硬化和肝癌。在啮齿类动物中发现维生素D3(VD3)具有抗氧化、抗凋亡、抗感染和抗肝纤维化的作用。补充VD3可部分改善NASH的进展。VD3有望成为临床治疗NASH的有效药物。更多还原

【Abstract】 Non-alcoholic steatohepatitis( NASH) is recognized as the most severe form of non-alcoholic fatty liver disease( NAFLD),with likely progression to liver cirrhosis and hepatocellular carcinoma. Vitamin D3( VD3) has been shown to act as an anti-oxidant,anti-apoptotic,anti-inflammatory and anti-fibrotic compound in rodents. VD3 supplementation partly ameliorated the NASH progression and thus can be an effective approach for the intervention in clinical NASH.更多还原