Objective To investigate the weekend effect of hand,foot and mouth disease( HFMD) reported in Shandong Province,and to provide evidence for the prevention and early warming of the epidemic. Methods All HFMD cases in Shandong Province was collected through China Information System for Disease Control and Prevention from 2010 to 2013,and analyzed by descriptive epidemiological method. Results 141 468,95 843,88 844 and 72 211 HFMD cases were reported,respectively. The peak incidence of HFMD occurred from April...