【摘要】 以异戊醛和丙二酸二甲酯为原料,经缩合、加成、催化氢化和水解脱羧得标题化合物,再用S-扁桃酸手性拆分和精制,得标题化合物产品,收率在27%以上,化学纯度和光学纯度均在99.9%以上。更多还原

【Abstract】 Pregabalin was obtained from isovaleraldehyde by condensation with dimethyl malonate,Michael addition,reduction,decarboxylation,resolution,dissociation and purification with the overall yield of above 27. 0% and HPLC purity( including optical purity) of above 99. 0%.更多还原