【摘要】 7Li离子属于高LET辐射,是辐射生物学基础研究中常用的重离子射线之一,它是硼中子俘获治疗癌症中起关键作用的离子,在辐射诱变育种等领域也有较好的应用前景。实验在北京HI-13串列加速器R20支线生物用新终端上进行,对43 MeV~7Li离子束照射野大小、均匀性和监测注量的准确性进行测量和评估,结果表明:5.0 cm×5.0 cm范围内照射野均匀性达到91.2%;4.2×10~4~1.5×10~5particles/cm~2/s注量率范围内,两种不同探测器测得的注量率变化呈线性关系,闪烁体探测器监测的注量与CR39探测器测得的绝对注量的误差小于10%。这些束流特性能够基本满足辐射生物学实验要求,有利于进一步开展与硼中子俘获治疗癌症或辐射诱变育种中~7Li离子的辐射生物学相关研究。更多还原

【Abstract】 ~7Li ion with high linear energy transfer(LET) radiation has been used in radiobiological research,which is key particle in Boron Neutron Capture Therapy(BNCT) and is applied in radiation mutagenic breeding.In present study, the new terminal had been established for radiobiological application, located at the end of R20 branch beam line of HI-13 tandem accelerator. The beam qualities of ~7Li ions of 43 Me V generated by HI-13 tandem accelerator, including spot size, uniformity and particle fluence accuracy, were measured using different detection methods. The results showed that beam uniformity was 91.2% at 5.0 cm×5.0 cm area, the flux measured using different detectors had a good linear relationship as particle flux ranged from 4.2 × 10~4particles/cm~2/s to 1.5×10~5particles/cm~2/s and particle fluence accuracy was better than 90%. All the results showed that the beam qualities of ~7Li ions basically met the requirements for radiation biological experiment. It provided important method to study biological effects in fundamental research and radiation therapy or radiation mutagenic breeding application associated with ~7Li ions.更多还原