Objective: To investigate the healing effect of mouse growth factor on skin injury of diabetic rats.Methods: SD rats were used in the present study. Rats were administered( i. p.) with streptozotoxin once for two days to prepare type I diabetic model,which blood glucose higher than 11. 1mmol / L were standardized.Thereafter,all the diabetic rats were divided into two groups to develop skin defect and skin scalded respectively. Then rats were treated with different doses( 3,6,12 μg / kg) m NGF once for 21 da...
【基金】
国家科技部“重大新药创制”专项(项目编号:2011ZX09201-301-03)
【更新日期】
2015-07-28
【分类号】
R587.2
【正文快照】
自发性皮肤溃疡或皮肤创面难愈是糖尿病常见的一类慢性并发症。糖尿病是以持续病理性高血糖为基本生化特征的代谢性疾病[1]。“微环境污染”假说认为:糖尿病代谢紊乱所致的皮肤组织局部高糖和晚期糖基化终末端产物(advanced glycation end production,AGE)蓄积引起的皮肤微环境
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