目的探讨单次人乳头状瘤病毒(human papillomavirus,HPV)DNA分型检测对意义未明的不典型鳞状细胞(atypical squamous cells of undetermined significance,ASCUS)分层处理的价值。方法对同时行HPV-DNA分型检测及宫颈细胞学检查确诊的ASCUS患者804例行阴道镜检查及镜下多点活检,分析HPV感染与宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)2及以上级别病变(CIN2+)的关系。结果 804例ASCUS患者高危型HPV感染460例(57.2%),高危型HPV阳性检出CIN2+的敏感性为90.9%(190/209),特异性为54.6%(325/595);高危HPV阳性者CIN2+检出率(41.3%)明显高于高危HPV阴性者(5.5%)(P<0.05);高危型HPV感染患者中16/18型阳性者CIN2+检出率(63.2%)明显高于其他高危型阳性组(29.3%)(P<0.01);HPV多重感染者CIN2+检出率(54.2%)明显高于HPV单一感染者(41.5%)(P<0.05)。结论单次HP...
【英文摘要】
Objective To explore the value of single HPV-DNA genotyping test to the triage of atypical squamous cells of undetermined significance(ASCUS).Methods A total of 804 patients with ASCUS confirmed by both HPV-DNA genotyping test and cervical cytology test underwent colposcopy with directed multiple punch biopsy.The relationship between HPV infection and cervical intraepithelial neoplasia grade 2or more advanced lesion(CIN2+)was analyzed.Results Among 804 ASCUS patients,460 had high-risk HPV infection(57.2%),t...
【基金】
湖南省科学技术厅资助项目(2012FJ4068)
【更新日期】
2015-11-17
【分类号】
R737.33
【正文快照】
意义未明的不典型鳞状细胞(atypical squamouscells of undetermined significance,ASCUS)是宫颈细胞学检查中常见异常细胞学形态,可能为炎症反应、宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)或浸润癌。ASCUS诊断的重复性低,且定期随访率不恒定,临床上对其进一步
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