【摘要】 目的 :利用1.5T核磁共振磁敏感加权成像(SWI)及扩散加权成像(DWI)对新生儿局灶性脑白质损伤中的T1WI高信号病灶机制进行探讨。方法 :选择2012年6月至2013年6月在我院确诊的局灶性脑白质损伤患儿42例,其中早产儿20例,足月儿22例,分别采用MR常规序列(T1WI、T2WI、FLAIR)、DWI及SWI序列进行扫描,对新生儿局灶性脑白质损伤T1WI高信号病灶机制进行探讨。结果 :38例SWI显示中等信号,与周围信号无差别,4例患儿SWI在双侧侧脑室后角旁发现斑片状低信号,其中早产儿1例,足月儿3例,经卡方检验,早产儿和足月儿PWML在SWI发生出血率无明显差异。50.0%(21)的病例在DWI上呈现高信号,早产儿组和足月儿组PWML在DWI上脑白质缺氧缺血的发生率无统计学差异。结论 :大多数新生儿脑白质损伤T1WI呈高信号病灶并不代表微出血,T1WI高信号产生主要与脑白质缺氧缺血、缺氧缺血-再灌注及出血三种病理改变同时或不同阶段存在有关。更多还原

【Abstract】 Objective To probe the machanism of SWI and DWI in T1 WI high singanl of neonatal Punctate white matter lesions. Methods From June 2012 to June 2013, 42 cases with PWML dignosed by MRI in our hospital was checkted by MRI(T1WI, T2 WI and FLAIR), DWI and SWI sequence can scan. We disscuss the machanism of the high signal intensity in the T1 WI. Results SWI in 38 cases of displayed medium signal, and there was no difference compared with the signals around. SWI in 4 cases underwent displayed low signal, and 1 case was premature infant and 3 cases was full-term children. There was no difference between preterm infants and full term by the chi-square test. 50.0%(21 cases) showed high signal on DWI, and between preterm infants and full term group, PWML in DWI on the incidence of brain hypoxic ischemia showed no statistical difference. Conclusion The high singal of T1 WI in PWML was not meaned micro bleeding in most neonatal. T1 WI signal was mainly associated with brain white matter hypoxic ischemia and hypoxic、ischemic-reperfusion and bleeding from the three kinds of pathological changes at the same time or at different stages.更多还原