【摘要】 目的探讨静脉溶栓与抗凝治疗对心源性脑栓塞患者临床疗效及应用价值。方法选取76例心源性脑栓塞患者为研究对象,根据其入院顺序分成静脉溶栓组(A组,n=38)和抗凝组(B组,n=38)2组。对比2组患者治疗前后美国国立卫生院神经功能缺损评分(NIHSS)及神经功能缺损程度评分(NFDS)评估结果,记录其日常生活能力(ADL)。结果治疗后2组患者NIHSS及NFDS评分均较治疗前显著降低,其中A组降幅大于B组,差异具有统计学意义(P<0.05);2组病死率差异无统计学意义(P>0.05);但A组ADL优良率为50.0%,显著高于B组的23.7%,差异具有统计学意义(P<0.05)。结论对心源性脑栓塞患者予以阿替普酶静脉溶栓疗法,疗效确切,值得临床推广。更多还原

【Abstract】 Objective To explore the differences of the application value of intravenous thrombolysis and anticoagulation therapy in the treatment of patients with cardiogenic cerebral embolism.Methods 76 patients with cardiogenic cerebral embolism were selected as the research objects and were divided into the intravenous thrombolysis group(group A,n=38)and the anticoagulation group(group B,n=38)according to the order of admission.The assessment results of American National Institutes of Health Stroke Scale(NIHSS)and Neural Function Defect Score(NFDS)of the two groups before and after the treatment were compared and the assessment of Activities of Daily Living(ADL)were recorded.Results After the treatment,NIHSS and NFDS of the two groups were significantly lower than those before the treatment.The fall of group A was greater than that of group B and the difference was statistically significant(P<0.05).The comparison of mortality in the two groups were not statistically significant(P>0.05);but the excellent and good rate of ADL in group A was 50%,which was significantly higher than 23.7% of group B and the difference was statistically significant(P<0.05).Conclusion The curative effect alteplase intravenous thrombolysis therapy for patients with cardiogenic cerebral embolism is definite and it is worthy of clinical promotion.更多还原