【摘要】 环境与癌症的发生密切相关.低氧微环境主要受缺氧诱导因子-1α(HIF-1α)调控.近年研究表明,低氧微环境HIF-1α可在癌症中高表达,参与癌细胞的生长繁殖、侵袭/迁移、新血管生成和细胞凋亡等过程.研究主要围绕肝癌、乳腺癌和胃癌等与HIF-1α的关系进行讨论.参32.更多还原

【Abstract】 The environment is closely related with the occurrence of cancer. Hypoxic microenvironment is mainly regulated by Hypoxia-inducible factor-1α( HIF-1α). In recent years,studies have shown that in hypoxia environment,HIF-1α could be abundantly expressed in many kinds of cancer,involved with the growth,invasion / migration,angiogenesis and apoptosis process of cancer cells. This article is mainly discussed around the relationship between HIF-1α and cancer such as liver cancer,breast cancer and gastric cancer. 32 refs.更多还原