Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives

【摘要】 Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives(C60-MMP),a novel chelating agent,was evaluated in mice.C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination.The molar ratio of chelating ligand/uranium was about 1:1.The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection.At 48 h after the last injection,uranium deposition in liver of C60-MMP treated mice is approximately 65%less than that of the control group.C60-MMP reacted positively in promoting the removal of uranium from kidney,and the urinary uranium excretion increased significantly,compared with the control and DTPA-treated mice.However,repeated administration of C60-MMP,and combined injection of DTPA and C60-MMP,did not show desirable effects on uranium removal from mice.It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.更多还原

【Abstract】 Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives(C60-MMP), a novel chelating agent, was evaluated in mice. C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1 : 1. The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection. At 48 h after the last injection, uranium deposition in liver of C60-MMP treated mice is approximately 65% less than that of the control group. C60-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However,repeated administration of C60-MMP, and combined injection of DTPA and C60-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.更多还原