【摘要】 目的观察胸腔灌注奈达铂(NDP)治疗非小细胞肺癌(NSCLC)恶性胸腔积液的临床效、患者生活质量及不良反应。方法随机将30例确诊为NSCLC(Ⅲb期)恶性胸腔积液患者分为两组,每组15例。观察组采用NDP治疗。对照组采用顺铂(DDP)治疗。比较两组临床疗效、不良反应及患者生活质量。结果观察组有效率、消化道不良反应发生率、Karnofsky评分以及生存期均显著优于对照组,差异具有统计学意义(P<0.05)。结论采用NDP胸腔灌注治疗NSCLC引起的恶性胸腔积液,临床效果显著,不良反应少,安全性高。更多还原

【Abstract】 Objective To observe the chest cavity perfusion of nida platinum( NDP) treatment of non- small cell lung cancer( NSCLC) patients with the clinical effect of the treatment of malignant pleural effusion,life quality and adverse reactions. Methods Random 30 patients diagnosed with NSCLC( Ⅲ b) malignant pleural effusion patients were divided into two groups,15 cases in each group. The observation group was treated using NDP. The control group treated with cisplatin( DDP). Compare two groups of patients with clinical efficacy,adverse reactions and quality of life. Results Observation group efficiently,the incidence of gastrointestinal adverse reactions,Karnofsky score and survival were significantly better than the control group,but it was not statisticated analysis because of less cases. the difference is statistically significant( P < 0. 05). Conclusions Using NDP pleural perfusion treatment of NSCLC malignant pleural effusion,clinical effect,less adverse reaction,high safety.更多还原