【摘要】 目的研究春、秋季室外颗粒物PM10、PM2.5及PM2.5-10的短期暴露对大学生肺功能1秒用力呼气量(FEV1)的影响。方法选取武汉市某大学2年级37名学生作为研究对象,采用固定群组追踪研究的方法,于2009年秋季(10月29日—11月11日,连续14 d)和2010年春季(3月24日—4月6日,连续14 d)两个时段内分别测定其早、晚FEV1,同时监测室外PM10、PM2.5浓度和温湿度变化。构建广义估计方程定量评价颗粒物暴露对学生FEV1的影响。结果春季PM10、PM2.5和PM2.5-10浓度每升高10μg/m3时,当晚FEV1分别下降0.20%(β的95%CI:-0.37%~-0.04%),0.48%(β的95%CI:-0.88%~-0.07%)和0.29%(β的95%CI:-0.53%~-0.04%),差异有统计学意义(P<0.05),但其滞后和累积效应无统计学意义(P>0.05)。秋季大气颗粒物的暴露与晚上FEV1无统计学关联(P>0.05),PM2.5-10浓度每升高10μg/m3时,滞后3 d的早上FEV1下降0.41%(95%CI:-0.81%~0.00%),差异有统计学意义(P<0.05)。结论武汉市春、秋季室外颗粒物的短期暴露对大学生FEV1存在急性影响,其中PM2.5-10暴露对肺功能的影响亦应引起重视。更多还原

【Abstract】 Objective To evaluate the acute effects of outdoor particulate matters(PM10,PM2.5 and PM2.5-10) on lung function of college students in spring and autumn.Methods A panel of 37 college students aged 19-21 in Wuhan were chosen and the investigation was carried out in autumn period(10/29/2009-11/11/2010,14 d) and spring period(3/24/2010-4/6/2010,14 d).Daily morning and evening forced expiratory volume in one second(FEV1) was measured by subjects themselves,respectively.Meanwhile,the daily data of outdoors PM10,PM2.5,temperature,and relative humidity were collected.Generalized Estimating Equations(GEEs) were used to estimate the association between particulate matter exposure and FEV1.Results In spring,a 10μg/m3 increment in concentrations of PM10,PM2.5 and PM2.5-10 on the current day corresponded to-0.20%(95%CI:-0.37%--0.04%),-0.48%(95% CI:-0.88%--0.07%) and-0.29%(95% CI:-0.53%--0.04%) changes of evening FEV1,respectively.In autumn,however,exposure to particulate matters were not associated with evening FEV1.10 μg/m3 increase in the concentration of PM2.5-10 resulted in changes of morning FEV1of-0.41%(95%CI:-0.81%-0.00%)(lag3).Conclusion Shortterm exposure to outdoor particulate matters in spring and autumn is significantly associated with acute changes of FEV1 in college students in Wuhan,and PM2.5-10 may play an important role in change of lung function.更多还原