【摘要】 目的:分析精神分裂症患者心肌酶谱和心电图异常的相关因素。方法:对2013年2月至2014年1月住院的164例精神分裂症患者进行血清谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸磷酸激酶同工酶(CPK-MB)等3项心肌酶检测和心电图检查,每周1次,连续4周,统计AST、LDH、CPK异常率和心电图异常率,并应用Logistic多因素回归分析影响患者心肌酶和心电图的危险因素。结果:精神分裂症患者治疗期间前4周心肌酶谱总异常率为50.6%,其中,AST异常率为34.8%,LDH异常率为37.2%,CPK-MB异常率为38.4%。前4周心电图总异常率为37.8%。较大剂量氯氮平、长时间联合用药、严重阳性症状、高血压和锥体外系反应是心肌酶谱异常和心电图异常的主要危险因素。结论:密切观察病情并定期监测心肌酶和心电图,控制危险因素,对指导治疗有参考价值。更多还原

【Abstract】 Objective: To analyze the factors related to abnormal cardiac muscle enzymes and electro-cardiogram in patients with schizophrenia. Method: From Feb. 2013 to Jan. 2014,164 cases inpatients with schizophrenia were tested cardiac muscle enzymes,serum aspartate aminotransferase( AST),lactate dehydrogenase( LDH),creatine phosphokinase-MB( CPK-MB) and electrocardiogram,once a week,for 4 weeks.The cardiac muscle enzymes abnormal rates and electrocardiogram abnormal rates were collected and factors related to abnormal cardiac muscle enzymes and electrocardiogram were analyzed with Logistic regression analysis. Result: During treatment,the incidence of abnormal cardiac muscle enzymes for 4 weeks was 50.6%.The incidences of abnormal AST,LDH and CPK-MB showed 34. 8%,37. 2% and 38. 4%,respectively. The total 4 weeks’ rate of abnormal electrocardiogram was 37.8%.Higher dosage of clozapine,longer time combination drugs,worse positive symptoms,hypertension and extrapyramidal side-reaction were main risk factors of abnormal cardiac muscle enzymes and electrocardiogram. Conclusion: It would be reference valuation in directing treatment to closely observate and periodically test electrocardiogram and cardiac muscle enzymes,and to control risk factors.更多还原