【摘要】 以3-苯基-1-茚酮（1）为原料,THF为溶剂,二异丙基氨基锂（LDA）为碱,与碘代烷（RI）经亲核取代反应合成了4个3-取代-3-苯基-1-茚酮类化合物（3a³d）,其中3b³d为新化合物,其结构经1H NMR,^<sup>13C NMR和EI-GC-MS表征。在最佳反应条件[1 1.0 eq.,LDA/RI=2.1/1.5（当量比）,于0℃^rt反应5 h]下,3a³d收率为70%⁸0%。更多还原

【Abstract】 Four 3-substituted-3-phenyl-1-indanone compounds( 3a ~ 3d,3b ~ 3d were novel compounds) were synthesized by nucleophilic substitution reaction of 3-phenyl-1-indanone( 1) with iodides( RI),using LDA as base and THF as solvent. The structures were characterized by1 H NMR,13 C NMR and EI-GC-MS. The yield of 3a ~ 3d were 70% ~ 80% under the optimum reaction conditions( 1 1. 0 eq.,LDA / RI = 2. 1 /1. 5,at 0 ℃ ~ rt for 5 h).更多还原