【摘要】 目的探讨肝移植治疗急性肝功能衰竭的经验及教训。方法回顾分析48例肝功能衰竭行肝移植的临床资料及随访结果。结果本组病例围手术期死亡3例(6.3%),随访期内死亡3例(6.3%),1年生存率91.7%,2年生存率89.6%,3年生存率87.5%。术后并发症包括肺部感染14例(29.2%),胸腔积液13例(27.1%),急性排斥反应5例(10.4%),慢性排斥反应3例(6.3%),胆道并发症7例(14.6%),术后急性肾衰竭4例(8.3%),肝移植相关性神经系统症状3例(6.3%)。结论肝移植是治疗肝功能衰竭的有效手段,合理选择手术适应证及手术时机,提高围手术期管理水平及手术技巧,是提高手术成功率、降低术后病死率的关键。更多还原

【Abstract】 Objective To evaluate liver transplantation treatment of acute liver failure.Methods Retrospective analysis was performed in the clinical data and follow-up results involved 48 cases of acute liver failure patients who underwent transplantation.Results The patients included perioperative death 3 cases(6.3%),3 cases of death in the follow-up period(6.3%),1 year survival rate 91.7%,2 year survival rate 89.6%,3 year survival rate 87.5%.Postoperative complications included pulmonary infection 14 cases(29.2%);pleural effusion 13 cases(27.1%);acute rejection 5 cases(10.4%);chronic rejection 3 patients(6.3%);biliary complications 7 patients(14.6%);postoperative acute renal failure 4 cases(8.3%);liver transplantation correlated nervous system symptoms 3 cases(6.3%).Conclusion Liver transplantation is an effective method for acute liver failure,it is a reasonable selection of surgical indications and surgical timing.Emphasis lies in improving the perioperative management and surgical techniques as the key to enhance the surgical success rate and lower postoperative mortality.更多还原