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湖北地区13例眼眶转移癌的临床分析

Metastatic Orbital Tumors:Clinical Analysis of 13 Cases in Hubei

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【作者】 武犁陈樱周芸芸

【Author】 WU Li;CHEN Ying;ZHOU Yunyun;Dept.of Ophthalmology,Renmin Hospital of Wuhan University;

【机构】 武汉大学人民医院眼科

【摘要】 目的:探讨湖北地区13例眼眶转移癌的原发部位、影像学表现、治疗转归等临床特征。方法:回顾性分析武汉大学人民医院眼科中心2000年12月至2014年12月期间经过手术后病理明确诊断的13例眼眶转移癌的临床表现、原发部位和影像学表现等。结果:这项研究包括8名男性和5名女性,年龄范围36-72岁(平均50.4岁)。所有的患者来自湖北地区。其中原发肿瘤最常见的是肺癌5例(38.5%),其次是乳腺癌2例(15.4%),肝癌2例(15.4%),胃癌、结肠癌、甲状腺癌、子宫恶性平滑肌肉瘤各1例(7.7%)。最常见的临床表现是眼球突出(84.6%)、眼球运动受限(69.2%)、复视(61.5%)、眼睑肿胀(38.5%)、视力下降(38.5%)和结膜充血(23.1%)。主要治疗包括手术切除、放疗、全身化疗和观察。有随访资料的10例(76.9%)患者(平均随访时间23.5个月)。结论:在湖北地区眼眶转移癌最常见的原发性癌症为肺癌,其次是乳腺癌和肝癌。眼眶转移癌可有多种临床表现,全身性肿瘤患者出现上述临床表现时需考虑此病。该病的预后普遍较差,手术可以改善其生存质量。

【Abstract】 Objective:To study the primary location,clinical characteristics,imaging findings of orbital metastatic tumors in Hubei province of China.Methods:The clinical features,the primary location and outcomes of 13 cases of metastatic orbital tumors admitted to our department from January 2000 to January 2014 were reviewed retrospectively.Results:The study included 8men and 5women.All patients were from Hubei Province.All the patients were performed the surgery.There were 5cases(38.5%)derived from lungs cancer,2cases(15.4%)from breast cancer,2cases(15.4%)from liver cancer and 1case(7.7%)from stomach cancer,colon cancer,malignant uterine leiomyosarcoma and thyroid cancer each.The most frequent ocular signs were proptosis(84.6%),limited ocular movement(69.2%),diplopia(61.5%),eyelid swelling(38.5%),decreased visual acuity(38.5%)and conjunctival hyperemia(23.1%).The main treatment included surgical excision,radiotherapy,chemotherapy and observation.Conclusion:The most common primary cancer that metastases to the ortibal is lung cancer followed by breast cancer and liver cancer in Hubei Province.Orbital metastasis can display a variety of clinical features and should be considered in patients with known systemic cancer.The systemic prognosis is generally poor and surgery can improve their quality of life.

【关键词】 眼眶转移肺癌
【Key words】 OrbitalMetastasisLung CancerTumor
  • 【文献出处】 武汉大学学报(医学版) ,Medical Journal of Wuhan University , 编辑部邮箱 ,2015年06期
  • 【分类号】R739.7
  • 【下载频次】48
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