Kunming mice were fed with high-level lipid feeds to establish the hyperlipidemic mice models.The mice were treated with earthworm lyophilized powder at dosages of 0.4,0.2and 0.1g/kg once a day and were fed with high-level lipid feeds at the same time for 10 weeks,the mice fed only with high-level lipid feeds were as the control.The total RNA of liver was extracted,and the changes of liver lecithin cholesterol acyltransferase and lipoprotein lipase gene expression were analyzed by RT-PCR.The results indicat...