【摘要】 目的研究细叶远志皂苷在大鼠四个肠段的吸收状况。方法运用大鼠在体单向肠灌流模型,采用重量法,研究细叶远志皂苷在不同肠段的吸收情况。结果在体小肠吸收实验中,细叶远志皂苷可被大鼠全肠段吸收,在十二指肠、空肠、回肠及结肠各肠段的药物吸收速率常数(Ka)分别是0.05922,0.06387,0.06345,0.06409s-1;药物表观吸收系数(Papp)分别是0.03322,0.03751,0.03733,0.04830cm·s-1,结肠段吸收最好(P<0.001)。结论细叶远志皂苷为全肠道吸收的药物,且结肠部位吸收最好。更多还原

【Abstract】 OBJECTIVE To study the absorption condition of tenuifolin in four intestine Segments in rats. METHODS In situ single pass perfusion model of rat was set up,taking gravimetry as a marker,the absorption of tenuifolin in small intestine was studied. RESULTS The tenuifolin could be absorbed in whole intestinal segments. The absorption rate constants(Ka) of tenuifolin at duodenum,jejunum,ileum and colon was 0. 05922,0. 06387,0. 06345,0. 06409s- 1,respectively; the apparent permeability coefficients(Papp) was 0. 03322,0. 03751,0. 03733,0. 04830cm·s- 1. Ka and Papp at colon were significantly higher than that at the other regions of intestine(P < 0. 001). CONCLUSION Tenuifolin can be absorbed in the whole intes-tinal,especially in colon.更多还原